Mass Spectrometry Scientist

This range is provided by Hamlyn Williams. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$100,000.00 / yr - $110,000.00 / yr

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Mass Spectrometry Scientist (Associate Scientist or Scientist I)

Position Type : Full-Time

Start Date : Immediate

Hamlyn Williams is partnered with a biotech in Los Angeles who is seeking a detail-oriented and scientifically rigorous Mass Spectrometry Scientist to oversee and execute analytical characterization of their growing pipeline of bioconjugate and antibody / peptide / oligo-based therapeutics. This role will be integral to their understanding of conjugation efficiency, in vivo pharmacokinetics, and molecular identity across platforms.

You will initially interface closely with external CROs and instrumentation partners to drive top-down mass spec analyses and in vivo PK quantification, later helping establish internal mass spec workflows as we build on-site capabilities. This is a unique opportunity to own analytical development in a fast-paced, platform-driven startup environment.

Key Responsibilities

• Lead or support regular mass spec-based QC of therapeutic conjugates using top-down proteomics, including intact mass confirmation and drug-to-antibody ratio (DAR) assessments.
• Perform and interpret bottom-up peptide mapping in collaboration with chemists and protein engineers.
• Analyze in vivo plasma and tissue samples to detect and quantify peptide or oligonucleotide species via LC-MS / MS, in partnership with CROs.
• Develop and standardize data processing and reporting pipelines, ensuring analytical rigor and reproducibility.
• Serve as a technical liaison with external mass spec providers and CROs, ensuring timely delivery, quality control, and method alignment.
• Contribute to the future build-out of internal mass spec capabilities—including equipment selection, workflow design, and SOP development.
• Collaborate cross-functionally with chemistry, biology, in vivo, and CMC teams to ensure integrated data flow for decision-making.

Basic Qualifications

Preferred Qualifications

Seniority level

Seniority level

Associate

Employment type

Employment type

Full-time

Job function

Job function

Science

Industries

Biotechnology Research and Pharmaceutical Manufacturing

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Inferred from the description for this job

Medical insurance

Vision insurance

401(k)

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